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Co-delivery all-trans-retinoic acid (ATRA) and paclitaxel (PTX) is an effective strategy for cancer therapy. However, in many previous reported ATRA conjugated co-delivery systems, the ATRA was released slower than PTX, and the total drug release of ATRA far lower than that of PTX.

international journal of nanomedicine

pH and redox dual-responsive copolymer micelles with surface charge reversal for co-delivery of all-&lt;em&gt;trans&lt;/em&gt;-retinoic acid and paclitaxel for cancer combination chemotherapy