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Bacillus Calmette-Guérin, the attenuated strain of Mycobacterium bovis , remains the only available vaccine against tuberculosis (TB). However, its ineffectiveness in adults against pulmonary TB and varied protective efficacy (0-80%) speak to an urgent need for the development of an improved and efficient TB vaccine. In this milieu, poly(lactic- co -glycolic acid) (PLGA), is a preferential candidate, due to such properties as biocompatibility, targeted delivery, sustained antigen release, and atoxic by-products.

international journal of nanomedicine

&lt;p&gt;Single-dose Ag85B-ESAT-6 loaded&amp;ndash;poly(lactic-&lt;em&gt;co&lt;/em&gt;-glycolic acid) nanoparticles confer protective immunity against tuberculosis&lt;/p&gt;