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Scaffold structure plays a vital role in cell behaviors. Compared with two-dimensional structure, 3D scaffolds can mimic natural extracellular matrix (ECM) and promote cell-cell and cell-matrix interactions. The combination of osteoconductive scaffolds and osteoinductive growth factors is considered to have synergistic effects on bone regeneration.

international journal of nanomedicine

Thermally induced self-agglomeration 3D scaffolds with BMP-2-loaded core&amp;ndash;shell fibers for enhanced osteogenic differentiation of rat adipose-derived stem cells