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Diabetic nephropathy (DN) is the primary root of morbidity and mortality in diabetic patients. Unfortunately, currently, no effective therapeutic strategies are available to ameliorate and reverse the progression of DN. Rhein (RH) is an anthraquinone derivative extracted from herbal medicines with various pharmacological effects on DN. However, its clinical administration is limited by its poor solubility, low bioavailability, reduced distribution into the kidney and adverse effects.

international journal of nanomedicine

Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol-&lt;em&gt;co&lt;/em&gt;-polycaprolactone-&lt;em&gt;co&lt;/em&gt;-polyethyleneimine nanoparticles for diabetic nephropathy therapy