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The interaction of Porphyromonas g ingivalis with commensal streptococci promotes P. gingivalis colonization of the oral cavity. We previously showed that a synthetic peptide (BAR) derived from Streptococcus gordonii potently inhibited the formation of P. gingivalis/S. gordonii biofilms (IC 50 =1.3 µM) and reduced P. gingivalis virulence in a mouse model of periodontitis. Thus, BAR represents a novel therapeutic to control periodontitis by limiting P. gingivalis colonization of the oral cavity. Here, we sought to develop drug-delivery vehicles for potential use in the oral cavity that comprise BAR-modified poly(lactic-co-glycolic)acid (PLGA) nanoparticles (NPs).

international journal of nanomedicine

Peptide-modified nanoparticles inhibit formation of &lt;em&gt;Porphyromonas gingivalis&lt;/em&gt; biofilms with &lt;em&gt;Streptococcus gordonii&lt;/em&gt;