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DNA methylation can induce carcinogenesis by silencing key tumor suppressor genes. Analysis of aberrant methylation of tumor suppressor genes can be used as a prognostic and predictive biomarker for cancer. In this study, we propose a colorimetric method for the detection of DNA methylation of the paired box gene 1 ( PAX1 ) gene in cervical scrapings obtained from 42 patients who underwent cervical colposcopic biopsy.

international journal of nanomedicine

Real-time colorimetric detection of DNA methylation of the &lt;em&gt;PAX1&lt;/em&gt; gene in cervical scrapings for cervical cancer screening with thiol-labeled PCR primers and gold nanoparticles