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Pyrazinamide (PZA) is a cornerstone of modern tuberculosis regimens. This study aimed to investigate the performance of genotypic testing of pncA  + upstream region, rpsA, panD, Rv2783c, and clpC1 genes to add insights for more accurate molecular diagnosis of PZA-resistant (R) Mycobacterium tuberculosis.

infection and drug resistance

&lt;p&gt;Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant &lt;em&gt;Mycobacterium tuberculosis&lt;/em&gt; Clinical Isolates in Southern China&lt;/p&gt;