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Direct-acting antivirals (DAA) facing resistance continue to be used in some areas worldwide. Thus, identifying hepatitis C virus (HCV) genotypes/subtypes and loci with certain prevalent resistance-associated substitutions (RASs) deserves attention. We investigated the global and regional frequencies of naturally occurring RASs among all confirmed HCV subtypes (n=86) and explored co-occurring and mutually exclusive RAS pairs within and between genes NS3 , NS5A , and NS5B .

infection and drug resistance

&lt;p&gt;Computational analysis of naturally occurring resistance-associated substitutions in genes &lt;em&gt;NS3&lt;/em&gt;, &lt;em&gt;NS5A&lt;/em&gt;, and &lt;em&gt;NS5B&lt;/em&gt; among 86 subtypes of hepatitis C virus worldwide&lt;/p&gt;