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Tachyplesin III , an antimicrobial peptide (AMP), provides protection against multidrug-resistant (MDR) bacterial infections and shows cytotoxicity to mammalian cells. Mixed bacterial infections, of which P. aeruginosa plus A. baumannii is the most common and dangerous combination, are critical contributors to the morbidity and mortality of long-term in-hospital respiratory medicine patients. Therefore, the development of effective therapeutic approaches to mixed bacterial infections is urgently needed.

infection and drug resistance

&lt;p&gt;Potential role of the antimicrobial peptide &lt;em&gt;Tachyplesin III&lt;/em&gt; against multidrug-resistant &lt;em&gt;P. aeruginosa&lt;/em&gt; and &lt;em&gt;A. baumannii&lt;/em&gt; coinfection in an animal model&lt;/p&gt;