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Microbial metabolism confounds antibiotic efficacy. However, information regarding effect of metabolism on cephalosporin antibiotics-mediated killing and Vibrio spp is largely absence, although the drugs are widely used in clinic and the bacteria are pathogens to both human and aquaculture animals.

<p>Metabolic mechanism of ceftazidime resistance in <em>Vibrio alginolyticus</em></p>