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The aim of this study was to evaluate the bactericidal effects of moxalactam (MOX), cefotaxime (CTX), and cefoperazone/sulbactam (CFZ/SBT) against extended-spectrum β-lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae , using an in vitro pharmacokinetics (PK)/pharmacodynamics model.

infection and drug resistance

Antibacterial effect evaluation of moxalactam against extended-spectrum &amp;beta;-lactamase-producing &lt;em&gt;Escherichia coli&lt;/em&gt; and &lt;em&gt;Klebsiella pneumoniae &lt;/em&gt;with in vitro pharmacokinetics/pharmacodynamics simulation