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The rise in community-acquired urinary tract infections (UTIs) with extended-spectrum β-lactamase (ESBL)-producing Escherichia coli strains raises the question of how to treat these infections effectively in pediatric outpatients. Amikacin has shown promising in vitro activity against ESBL-producing urinary isolates of E. coli ; however, clinical data are limited.

infection and drug resistance

Once-daily intramuscular amikacin for outpatient treatment of lower urinary tract infections caused by extended-spectrum &amp;beta;-lactamase-producing &lt;em&gt;Escherichia coli&lt;/em&gt; in children