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The patatin-like phospholipase domain containing protein 3 ( PNPLA3 ) rs738409 polymorphism (c.444C&gt;G) is the most well-known genetic risk factor for non-alcoholic fatty liver disease (NAFLD), but whether or not physical activity influences the association between the PNPLA3 genotype and risk of NAFLD is unclear.

diabetes, metabolic syndrome and obesity

&lt;p&gt;A Pilot Study Assessing the Possible Combined Effect of Physical Activity and &lt;em&gt;PNPLA3&lt;/em&gt; rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population&lt;/p&gt;