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Diabetes is commonly associated with gastrointestinal dysfunction. We have previously shown that transepithelial short circuit current, I sc (chloride secretion), is significantly reduced in the jejunum from ob/ob mice vs lean controls, and consumption of 600 mg genistein/kg of diet (600 G) for 4 weeks significantly rescues I sc . We aimed to evaluate whether morphological changes in the jejunal crypts contribute to the rescue of I sc .

Genistein diet does not modify crypt morphology in the ob/ob mouse jejunum: a comparison of cryostat and clearing techniques