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The beneficial, neuroprotective effects of curcumin against ischemia-reperfusion injury have been demonstrated. In the present study, whether curcumin exerts neuroprotective effects associated with the inhibition of autophagy and hypoxia inducible factor-1α (HIF-1α) was investigated.

drug design, development and therapy

&lt;p&gt;The neuroprotective effects of curcumin are associated with the regulation of the reciprocal function between autophagy and HIF-1&amp;alpha; in cerebral ischemia-reperfusion injury&lt;/p&gt;