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Neurotoxicity is a major obstacle to the effectiveness of cisplatin (CDDP) in cancer chemotherapy. Oxidative stress and inflammation are considered to be the major mechanisms involved in CDDP-induced neurotoxicity. The rationale of our study was to investigate the efficacy of N -acetylcysteine (NAC) at two different doses in the management of CDDP-induced toxicity in rat brain by monitoring its antioxidant and anti-inflammatory effects.

drug design, development and therapy

&lt;p&gt;Neuroprotective effect of &lt;em&gt;N&lt;/em&gt;-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation&lt;/p&gt;