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Intra-articular injection of sinomenine (SN) is an effective treatment method for knee osteoarthritis (OA), however, SN could be eliminated quickly in vivo. To extend the residence time of SN in the joint cavity, the SN-hyaluronic acid (HA) conjugate was prepared previously. This study was performed to evaluate the pharmacokinetics and pharmacodynamics of SN-HA conjugate after intra-articular administration for the treatment of OA.

drug design, development and therapy

&lt;p&gt;Evaluation of pharmacokinetics and pharmacodynamics of sinomenine-hyaluronic acid conjugate after intra-articular administration for osteoarthritis treatment&lt;/p&gt;