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As a novel antidepressant drug, agomelatine has good therapeutic effect on the mood disorder and insomnia in Alzheimer's disease (AD). Recent studies have shown the neuroprotective function of agomelatine, including anti-oxidative and anti-apoptosis effect. However, it remains unclear whether agomelatine exerts neuroprotection in AD. Thus, the neuroprotective effect of agomelatine against amyloid beta 25-35 (Aβ 25-35 )-induced toxicity in PC12 cells was evaluated in this study.

<p>Melatonin receptor stimulation by agomelatine prevents A&beta;-induced tau phosphorylation and oxidative damage in PC12 cells</p>

<p>Melatonin receptor stimulation by agomelatine prevents Aβ-induced tau phosphorylation and oxidative damage in PC12 cells</p>