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The tumor suppressor protein p53 plays an important role in preventing tumor formation and progression through its involvement in cell division control and initiation of apoptosis. Mdm2 protein controls the activity of p53 protein through working as ubiquitin E3 ligase promoting p53 degradation through the proteasome degradation pathway. Inhibitors for Mdm2-p53 interaction have restored the activity of p53 protein and induced cancer fighting properties in the cell.

Identification of new inhibitors of Mdm2&ndash;p53 interaction via pharmacophore and structure-based virtual screening

Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening