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Hormone-dependent breast cancer is the most common form of breast cancer, and inhibiting 17β-HSD1 can play an attractive role in decreasing estrogen and cancer cell proliferation. However, the majority of existing inhibitors have been developed from estrogens and inevitably possess residual estrogenicity. siRNA knockdown provides a highly specific way to block a targeted enzyme, being especially useful to avoid estrogenicity. Application of 17β-HSD1-siRNA in vivo is limited by the establishment of an animal model, as well as the potential nuclease activity in vivo. We tried to reveal the in vivo potential of 17β-HSD1-siRNA-based breast cancer therapy.

drug design, development and therapy

&lt;p&gt;siRNA-based breast cancer therapy by suppressing 17&amp;beta;-hydroxysteroid dehydrogenase type 1 in an optimized xenograft cell and molecular biology model in vivo&lt;/p&gt;