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Anti-oxidative stress and inhibition of TGF-β1/Smads signaling cascade are essential therapeutic strategies for diabetic nephropathy (DN). In this study, we aimed to explore the effect of combination of Ginsenoside Rg1 and Astragaloside IV on oxidative stress and TGF-β1/Smads signaling in DN rats.

drug design, development and therapy

Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-&amp;beta;1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy