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Over the years, pyrazolopyrimidine derivatives have been recognized as having antimicrobial activities. Recently, we reported different synthetic methods to prepare pyrazolopyrimidine derivatives as anticancer and antimicrobial agents. The studies showed that our previously reported 5-aminopyrazoles 2 act as a building block for the preparation of a variety of interesting pyrazolopyrimidines as purine analogs.

drug design, development and therapy

Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-&lt;em&gt;a&lt;/em&gt;]pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs