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Previous studies in our laboratory demonstrated that a synthetic peptide containing lung surfactant enhances the permeability of chemical compounds through bronchial epithelium. The purpose of this study was to test two formulations of Synsurf ® combined with linezolid as respirable compounds using a pressurized metered dose inhaler (pMDI).

drug design, development and therapy

Deposition and transport of linezolid mediated by a synthetic surfactant Synsurf&lt;sup&gt;&amp;reg;&lt;/sup&gt; within a pressurized metered dose inhaler: a Calu-3 model