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Patients with COPD show a significant reduction of the lobar hyperinflation at the functional residual capacity level in the patients who improved &gt;120 mL in forced expiratory volume in 1 second (FEV1) after 6 months of treatment with roflumilast in addition to inhaled corticosteroids (ICSs)/long-acting beta-2 agonists (LABAs)/long-acting muscarinic antagonists (LAMAs).

Functional respiratory imaging to assess the interaction between systemic roflumilast and inhaled ICS/LABA/LAMA