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Combining bronchodilators with different mechanisms of action may improve efficacy and reduce risk of side effects compared to increasing the dose of a single agent in chronic obstructive pulmonary disease (COPD). We investigated this by combining two long-acting bronchodilators: once-daily muscarinic antagonist tiotropium and once-daily β2-agonist olodaterol.

international journal of chronic obstructive pulmonary disease/international journal of copd

Efficacy and safety of combining olodaterol Respimat&amp;reg; and tiotropium HandiHaler&amp;reg; in patients with COPD: results of two randomized, double-blind, active-controlled studies