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We recently reported that epithelial-mesenchymal transition (EMT) is active in the airways in chronic obstructive pulmonary disease (COPD), suggesting presence of an active profibrotic and promalignant stroma. With no data available on potential treatment effects, we undertook a blinded analysis of inhaled corticosteroids (ICS) effects versus placebo on EMT markers in previously obtained endobronchial biopsies in COPD patients, as a "proof of concept" study.

international journal of chronic obstructive pulmonary disease/international journal of copd

A randomized controlled trial of inhaled corticosteroids (ICS) on markers of epithelial&amp;ndash;mesenchymal transition (EMT) in large airway samples in COPD: an exploratory proof of concept study