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Ophiocordyceps sinensis ( C. sinensis ) extracts have been found to have a therapeutic effect on patients with chronic obstructive pulmonary disease (COPD). Silent information regulator 1 (SIRT1) plays an important role in the regulation of inflammatory mediators and correlates with lung function and COPD exacerbations. The objective of this work was to explore the anti-inflammatory effect and preliminary pathways of nucleosides from cultured C. sinensis on RAW264.7 macrophages and COPD mice.

international journal of chronic obstructive pulmonary disease/international journal of copd

Nucleosides isolated from &lt;em&gt;Ophiocordyceps sinensis&lt;/em&gt; inhibit cigarette smoke extract-induced inflammation via the SIRT1&amp;ndash;nuclear factor-&amp;kappa;B/p65 pathway in RAW264.7 macrophages and in COPD mice