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This study aimed to investigate the impact of cigarette smoke exposure upon CD40-CD40L ligation between bone marrow-derived dendritic cells (BMDCs)and CD4 + T cells, and to examine the effects of cigarette smoke exposure upon differentiation of CD4 + T cells toward Th17 cells through blockade of CD40-CD40L pathway in mice.

Cigarette smoke exposure promotes differentiation of CD4<sup>+</sup>T cells toward Th17 cells by CD40-CD40L costimulatory pathway in mice