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Large clinical trials have confirmed the long-term efficacy of inhaled corticosteroid/long-acting β 2 -agonist combinations in patients with chronic obstructive pulmonary disease (COPD). It was hypothesized that significant treatment effects would already be present within 3 months after the initiation of treatment across a range of clinical outcomes, irrespective of COPD severity.

Early efficacy of budesonide/formoterol in patients with moderate-to-very-severe COPD