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Colorectal cancer is one of the most common malignant tumors worldwide. As CD133 and CD44 are notable markers of cancer stem cells (CSCs) identity, it is thought to be a predictive indicator for colorectal cancer. The aim of this study was to investigate the cell cycle state of CD133 + CD44 + and CD133 - CD44 - cells, isolated from primary human colorectal tumors, and to assess the clinical impact of CD133 + CD44 + CSCs on patients' outcome regarding disease-free survival (DFS) and overall survival (OS).

cancer management and research

&lt;p&gt;Pretreatment detection of circulating and tissue CD133&lt;sup&gt;+&amp;nbsp;&lt;/sup&gt;CD44&lt;sup&gt;+&lt;/sup&gt; cancer stem cells as a prognostic factor affecting the outcomes in Egyptian patients with colorectal cancer&lt;/p&gt;