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Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, which is associated with a high incidence of lymph-node metastasis. Multiple biomarkers have been identified for the precise diagnosis of PTC at an early stage. However, their role in PTC remains poorly elucidated. Previously, we reported that lipase H (LIPH), a membrane-bound protein, was highly expressed in PTC. This study aimed to fully elucidate the causal role of LIPH in the development of PTC and investigated its relationship with lymph-node metastasis in PTC.

cancer management and research

&lt;p&gt;Lipase member H is a downstream molecular target of hypoxia inducible factor-1&amp;alpha; and promotes papillary thyroid carcinoma cell migration in BCPAP and KTC-1 cell lines&lt;/p&gt;