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Metformin, a first-line antidiabetic drug, has recently been reported with anticancer activities in various cancers; however, the underlying mechanisms remain elusive. The aim of the present study was to investigate the role of cellular FADD-like IL-1β-converting enzyme (FLICE)-inhibitory protein large (c-FLIP L ) in metformin-induced anticancer activity in non-small cell lung cancer (NSCLC) in vitro.

cancer management and research

Metformin induces apoptotic cytotoxicity depending on AMPK/PKA/GSK-3&amp;beta;-mediated c-FLIP&lt;sub&gt;L&lt;/sub&gt; degradation in non-small cell lung cancer