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A link between poor sleep quality and Alzheimer's disease (AD) has recently been suggested. Since endogenous melatonin levels are already reduced at preclinical AD stages, it is important to ask whether replenishing the missing hormone would be beneficial in AD and whether any such effects would be related to the presence of sleep disorder in patients.

clinical interventions in aging

Add-on prolonged-release melatonin for cognitive function and sleep in mild&amp;nbsp;to moderate Alzheimer&amp;rsquo;s disease: a 6-month, randomized, placebo-controlled, multicenter trial