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Kyphosis is a spine deformity that can lead to falls and reduced quality of life. Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) regulates mitochondrial biogenesis and is important for proper functioning of skeletal muscle, including the paraspinal muscles, which support and allow movement of the spine. The role of PGC-1α in paraspinal muscles in lumbar kyphosis has not been examined. We also examined the expressions of the proinflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6.

clinical interventions in aging

mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1&amp;alpha;, tumor necrosis factor-&amp;alpha;, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study