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In 2012, the European Medicines Agency reviewed the safety of dual renin-angiotensin system (RAS) blockade because of potentially increased risks for inter alia acute kidney injury (AKI). Since residents of nursing homes are particularly vulnerable to adverse drug outcomes, the aims of our study were to describe RAS-inhibiting drug use in German nursing home residents and examine the risk of AKI associated with dual RAS blockade.

clinical interventions in aging

Combined use of drugs inhibiting the renin&amp;ndash;angiotensin system: prescribing patterns and risk of acute kidney injury in German nursing home residents