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Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent.

clinical interventions in aging

&lt;sup&gt;11&lt;/sup&gt;C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer&amp;rsquo;s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia