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Lactose malabsorption is normally evaluated by measuring exhaled H 2 produced by intestinal flora, from unabsorbed lactose. However, differing microbiome composition can lead to the production of CH 4 instead of H 2 ; hence, some authors challenge the H 2 method sensitivity and favor the evaluation of both intestinal gases.

clinical and experimental gastroenterology

Retrospective analysis of a lactose breath test in a gastrointestinal symptomatic population of Northeast Italy: use of (H&lt;sub&gt;2&lt;/sub&gt;+2CH&lt;sub&gt;4&lt;/sub&gt;) versus H&lt;sub&gt;2&lt;/sub&gt; threshold