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Cohesive polydensified matrix (CPM ® ) hyaluronic acid fillers are now available with or without lidocaine. The aim of this study was to investigate the safety and performance of CPM ® fillers with lidocaine in the clinical setting. In an open-label, prospective, postmarketing study, 108 patients from seven sites in Germany and Denmark were treated with one or more lidocaine-containing CPM ® fillers. Performance was assessed using the Merz Aesthetics Scales ® (MAS). Pain was rated on an 11-point visual analog scale. Patients' and physicians' satisfaction as well as adverse events were recorded. Improvements of ≥1-point on MAS immediately after and 17 days posttreatment were observed in ~90% of patients compared with baseline. All investigators assessed ejection force, product positioning, and performance as similar or superior to the respective nonlidocaine products. Overall, 94% of investigators were satisfied with the esthetic outcomes and were willing to continue using the products. All patients except one were satisfied with the results, and all were willing to repeat the treatment. Mean pain scores were low during (&lt;3.0) and after injection (&lt;0.6). Except for one case of bruising, all adverse events were mild to moderate. CPM ® fillers with lidocaine are safe and effective for a wide range of esthetic facial indications.

clinical, cosmetic and investigational dermatology

Safety and performance of cohesive polydensified matrix hyaluronic acid fillers with lidocaine in the clinical setting &amp;ndash; an open-label, multicenter study