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Several recent randomized controlled trials (RCTs) in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC) have demonstrated significant improvements in progression-free survival (PFS); however, few have reported improvement in overall survival (OS). The surrogacy of PFS or time to progression (TTP) for OS has not been formally investigated in HR+, HER2- MBC.

Progression-free survival/time to progression as a potential surrogate for overall survival in HR+, HER2&ndash; metastatic breast cancer

Progression-free survival/time to progression as a potential surrogate for overall survival in HR+, HER2– metastatic breast cancer