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Fluoroquinolone antimicrobials exhibit inhibitory and bactericidal activity by blocking DNA gyrase (topoisomerase II), an essential bacterial enzyme.1 These compounds possess excellent antimicrobial activity against bacterial and mycoplasmal pathogens, however few in-vitro studies have been conducted to evaluate the activity of fluoroquinolone antimicrobials against respiratory pathogens of veterinary significance2,3,4 This report summarizes the results of an extensive survey to determine Minimum Inhibitory Concentrations (MIC) of danofloxacin*, a new fluoroquinolone antimicrobial, and six commonly used antibacterials against P. haemolytica, P. multocida, and H.somnus isolated from pneumonic cattle.

american association of bovine practitioners conference

Comparative Minimum Inhibitory Concentrations of Danofloxacin and Six Commonly Used Antibacterials Against Pasteurella and Haempophilus From Pneumonic Cattle