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When two types of clonal cell populations competitively grow in epithelial tissues, only at the boundary between the two clones, apoptosis selectively occurs in the cells with lower division rate. Although genetic studies have suggested that F-actin dependent mechanical force is a major regulator of cell competition, how the difference of division rates affects the mechanical force is little investigated. Using the cell vertex model, we numerically found that the boundary of the clones was more smoothly rounded only as the difference of division rates increases. This boundary shape is consistent with experiments in Drosophila. Moreover, the slower dividing cells exhibited boundary-specific abnormalities not only in cell shape, but also in tensile force.

seibutsu butsuri/seibutsu butsuri

3P272 Interface mechanics between two clonal cell populations with different growth rates : A theoretical study of cell competition(24. Mathematical biology,Poster)