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Communication between tissues and organs plays an important role in the maintenance of normal physiological functions as well as the occurrence and development of diseases. Communication molecules act as a bridge for interactions between tissues and organs, playing not only a local role in the tissues and organs where they are secreted but also in exerting systemic effects on the whole body via circulation. In this study, blood microRNA-omics analysis of overfed vs. normally fed (control) Landes geese revealed that the content of each of the 21 microRNAs (miRNAs) in the blood of overfed geese was significantly higher than that in the blood of control geese. These miRNAs may have systematic effects in the development of goose fatty liver as well as being candidate markers for the diagnosis of goose fatty liver. We determined the expression of miR-143, miR-455-5p, miR-222a-5p, miR-184, miR-1662 , and miR-129-5p using quantitative PCR in goose fatty liver vs. that in normal liver. The expression of these miRNAs, except miR-129-5p , in goose fatty liver was also significantly higher than that in normal liver ( P &lt;0.05), suggesting that these blood miRNAs are released from goose fatty liver. In addition, we found that expression of IGFBP5 , the predicted target gene of miR-143 , was significantly decreased in goose fatty liver vs. the normal liver ( P &lt;0.05), indicating that miR-143 may exert both local and systematic effects by inhibiting the expression of IGFBP5 , thus promoting the development of goose fatty liver. In conclusion, we identified several miRNAs, including those we validated (i.e., miR-143, miR-455-5p, miR-222a-5p, miR-184, miR-1662 , and miR-129-5p ) that may serve as candidate markers in the diagnosis of goose fatty liver as well as local and global regulators contributing to the development of goose fatty liver.

Screening of MicroRNAs with Potential Systemic Effects Released from Goose Fatty Liver