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<p class="noindent">We present and illustrate the methodology to calculate curvature measures for continuous designs, and extend design criteria to incorporate continuous designs. These design algorithms include quadratic design procedures, a subset design criterion, a second-order mean-square error design criterion, and a marginal curvature design methodology. A discussion of confidence intervals is also provided for continuous designs. </p>

Curvature measures for nonlinear regression models using continuous designs with applications to optimal experimental design