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The aim of the paper is to present regional business framework which affects small and medium-sized enterprises’ development. The paper presents results  of own empirical research, which  were conducted in late-2004 year within two groups: entrepreneurs and local authorities. The research was restricted to two provinces in southern Poland (Lesser Poland Voivodeship - Małopolska and Silesian Voivodeship - Śląsk), which make up one region within the EU NUTS classification (region II). The first research group consisted of 109 micro, small and medium-sized firms random sample and the second one of 150 commune authorities. The empirical study was based on the numerous questions, which thematically can be divided into three groups: local business environment, the entrepreneurial attitude of the owner and the characteristics of the firm as well as the development of a firm.In entrepreneurs’ perceptions nationalwide factors (96,2%) and entrepreneurial attitude of entrepreneurs (94,3%) matter most on development of small and medium-sized enterprises, but regional factors in entrepreneur’s opinions also play a very important role (76,5%). The factors based in regional business environment can be divided into two groups: stimuli and barriers. On the basis of empirical research it is possible to determine upon sixteen barriers and stimuli of small and medium-sized enterprises development, in addition to which it is worth underlining, that they are common for the whole studied community, as only in two incidents statistical essential differences were proved. As far as legal form is concerned differences of financial support evaluation were affirmed (χ2 = 8,43 at p = 0,07, χ2 YATESA = 9,05 at p = 0,06). One-man private enterprises considerably more often than remaining enterprises defined this factor as a barrier. Industrial enterprises in predominant majority (considerably more often than remaining enterprises) defined public financial support as a barrier of small and medium-sized enterprises  development (χ2 = 26,2 near p = 0,03), but in addition to which the level of significance in first case is rather weak. Taking additionally the percentages of confirmed dependences into account, which carried out 3% (16 factors x 4 variables characterizing each enterprise) it can be commonly accepted, that the prepared on the basis of empirical research composition of barriers and stimuli is typical for the all studied enterprises, which allow for generalizations in this range.

Regional Barriers and Stimuli of SMEs Development in Southern Poland