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The distribution of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate (KB-2413) was studied in rats after single and multiple oral administrations of KB-2413-14C. The radioactivity was high in the intestine, liver, pancreas and kidney, and low in the central nervous system and in the fat after single oral administration to fasted rats. The steady-state during multiple oral administration, was reached after the 7 th dose as shown by a constant values of the tissue-to-plasma concentration ratio and AUC0-24h. The radioactivity excreted into both urine and feces was about 98 % within 4 d after the 14 th administration. At this time, the concentration in most tissues was lower than that at 24 h after the 1 st administration.

yakubutsu dōtai

The biological fate of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate (KB-2413). II. Distribution after single and multiple oral administration to rats.