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Eleven sulfur-containing conjugates were determined in the bile of rats administered with m-DCB. Mercapturic acid conjugate concentration in urine after administration of m-DCB to bile duct-cannulated rats was measured. 1. Follow ing administration of m-DCB to rats, the main metabolites in the bile were glutathione conjugates. The amount of H2·OH-2, 4 and H2·OH-3, 5-DCPGs accounted for about 35% of the administered dose that corresponded to 2/3 of the biliary metabolites. The biliary excretions of H2·OH-3, 5-DCPC, 3, 5-DCPGs, H2·OH-3, 5-DCPCG, 2, 4-DCPGs, MCPG, 3, 5-and 2, 4-DCPCs, and 2, 4-and 3, 5-DCPMs, within 4 days after administration, accounted for 5%, 4%, 3.5%, 3%, 2%, 2%, 1%, 0.1% and 0.04% of the administered dose, respectively. The sum of sulfur-containing metabolites in the bile accounted for 56% of the dose. 2. The amount (about 34% of the dose) of two mercapturic acid conjugates excreted to urine over 48-hr period after the administration of m-DCB, markedly decreased to 1/4 (about 8% of the dose) in the bile duct cannulated rats. 3. The metabolic pathway of sulfur-containing metabolites of m-DCB in rats was postulated.

Concentration of the Sulfur-containing Metabolites of m-Dichlorobenzene in Rats Bile and Urine.