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MRP and cMOAT are the organic anion transporters involved in the efflux of organic anions from cells. We have already found two novel cDNA sequences (MLP-1 and -2: MRP like protein) which show high homology with MRP and cMOAT. Liver expression of MLP-2 was observed only in mutant rats (EHBR) whose cMOAT is hereditarily defective, suggesting that MLP-2 is an inducible transporter. MLP-2 is induced in normal rat liver by injection of phenobarbital, ANIT and bile duct ligation. In normal rats, MLP-2 is expressed mainly in the duodenum and jejunum. To clarify the nature of the organic anion transport mechanism in the intestine, we used Caco-2 cells as an intestinal model. DNP-SG and estradiol 17 β-D-glucuronide were taken up by BBMV prepared from Caco-2 in an ATP-dependent manner. Northern blot analysis suggested high expression of human cMOAT and MLP-2 and low expression of MRP in cultured Caco-2 cells.

Role of MRP family proteins in the export of organic anion compounds from liver and intestine