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Objective The present study aimed to clarify the pulmonary disposition of a cyclosporine derivative, IMM 125 (IMM), inhaled as a dry powder consisting of micronized particles for the treatment of asthma. The physiological mechanism of pulmonary accumulation of IMM, as well as the relative exposure of such an immunosuppresive drug between systemic and local (target) sites, were particularly investigated in order to assess the advantages of the inhalation route in comparison with a systemic one.

PHARMACOKINETIC ASSESSMENT OF PULMONARY ABSORPTION AND ACCUMULATION AFTER INHALATION OF A CYCLOSPORINE DERIVATIVE, IMM 125