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Chloropeptide, a hepatotoxic mycotoxin of Penicillium islandicum Sopp, induces gross changes in cell morphology including blebbing and ballooning of the cytoplasmic membrane in the isolated hepatocytes, and this hepatotoxic potential of chloropeptide is abolished by microsomal cytochrome P-450 system.

Cytotoxicity of chloropeptide in isolated hepatocytes and its inactivation by microsomes.