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Acute oral toxicity of the three Beta-adrenoceptor stimulants Orciprenalin, Fenoterol and Salbutamol as well as the two Beta-adrenoceptor blockers Pindolol and Bunitrolol was studied in singly-housed and aggregated male and female mice (ICR-JCL) and the results were compared with those in grouped mice (background studies). With a few exceptions, the acute toxic potency of the five test substances in mice appeared to be: Aggregated mice greater than grouped mice greater than singly-housed mice.

Oral acute toxicity with stimulants and blockers of beta-adrenoceptors in singly-housed or aggregated mice.